ASSESSMENT OF THE ANTINOCICEPTIVE EFFECTS OF CANNABINOID RECEPTOR AGONISTS SER 601 AND L-759,633 IN AN ACUTE PAIN MODEL IN RATS

A poorly managed pain is associated with many negative results. These results disturb patients, their families and societies. Although opioid agents have extraordinary analgesic efficacy, they may cause serious adverse consequences. For medication of pain, there a medical need to discover possible alternatives opioids. In animal models acute synthetic cannabinoid receptor agonists demonstrated effects. Selective activation the 2 in rodent does not psychotropic effects therefore CB2R are an appealing target for other pathologies. this study we examined antinociceptive activity (CB2) SER 601 L-759,633 different doses rat using hot plate tail flick tests. two exhibited dose-dependent model. The administrated reached peak at 60 min. test, 3, 6 12 mg / kg SER601 were more than groups same doses.